Posted by: getthenac | December 15, 2010

Yohimbine and Head Rush

from Leigh MacMillan:

Orthostatic hypotension – a sudden drop in blood pressure that causes dizziness and near-fainting (a “head rush”) – is the main cause of disability in patients with autonomic failure, a disorder of the nervous system that normally controls functions like heart rate, digestion and respiration.

Cyndya Shibao, Italo Biaggioni, M.D., and colleagues compared the ability of two different drugs (alone and in combination) to improve blood pressure on standing in 31 patients with severe autonomic failure. They report in the November issue of Hypertension that the drug yohimbine – a plant-derived compound with stimulant and aphrodisiac effects – significantly improved standing blood pressure compared to placebo, and that pyridostigmine did not. Yohimbine and pyridostigmine in combination did not improve blood pressure more than yohimbine alone.

Because yohimbine increases blood pressure by activating the sympathetic nervous system, the findings suggest that patients with autonomic failure still have residual sympathetic activity and that this mechanism is an important therapeutic target.

 

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Categories

%d bloggers like this: